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KMID : 0615720130300040069
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Jouranl of Korean Acupuncture and Moxibustion society
2013 Volume.30 No. 4 p.69 ~ p.78
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The Effects of Eucommiae Cortex Pharmacopuncture Injected at Sinsu(BL23) on Neuropathic Pain in Rats
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Lee Dong-Geun
Lee Ook-Jae
Lee Ju-Hee
Lee Sang-Hyun
Lee Jung-Hun
Shin Jeong-Cheol
Kim Jae-Hong
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Abstract
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Objectives : The purpose of this study is to examine whether Eucommiae Cortex pharmacopuncture may affect to the neuropathic pain in a rat model.
Methods : To produce the model of neuropathic pain, under isoflurane 2.5 % anesthesia, underwent tight ligation by 6.0 silk thread and transection of the tibial and sural nerves, leaving the common peroneal nerve intact. After neuropathic surgery, the author examined if the exhibited the behavioral sign of allodynia. The allodynia was assessed by stimulating the plantar with Dynamic Plantar Aesthesiometer. Three days after the neuropathic surgery, Eucommiae Cortex pharmacopuncture was injected at Sinsu(BL23) once every week for 6 weeks. After that, the author examined the withdrawal response of neuropathic rats’ leg by Dynamic Plantar Aesthesiometer.
And also the author examined Bax, Bcl-2, Bax/Bcl-2 ratio in the spinal cord of neuropathic rats and the change of WBC, RBC, HGB, HCT count in the blood of neuropathic rats.
Results :
1.The Eucommiae Cortex pharmacopuncture decreased the withdrawal response of mechanical allodynia that assessed with Dynamic Plantar Aesthesiometer in EC2-BL23 group as compared with control group.
2.The Eucommiae Cortex pharmacopuncture decreased Bax/Bcl-2 ratio in EC1-BL23, EC2-BL23 group. But The Eucommiae Cortex pharmacopuncture injected at Sinsu(BL23) didn’t change Bax, Bcl-2 expression level in the all group.
3.The Eucommiae Cortex pharmacopuncture decreased WBC count in EC1-BL23, EC2-BL23 group.
Conclusions : We have noticed that Eucommiae Cortex pharmacopuncture decreased mechanical allodynia in the model of neuropathic pain compared with the control group. Bax/Bcl-2 ratio in spinal cord of that group was also decreased compared with the control group. This study can be used as a basic resource on a study and a treatment of neuropathic pain.
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KEYWORD
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Neuropathic pain, Eucommiae Cortex pharmacopuncture, Sinsu(BL23).
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